THE ARG16GLYβ_2-ADRENERGIC RECEPTOR POLYMORPHISM INFLUENCES LONG TERM CLINICAL RESPONSES TO β_2-AGONIST

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  • Isada Akira
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Hizawa Nobuyuki
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Shimizu Kenichi
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Shimizu Kaoruko
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Takahashi Ayumu
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Hattori Takeshi
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Maeda Yukiko
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Takahashi Daisuke
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Konno Satoshi
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine
  • Nishimura Masaharu
    Department of Respiratory Medicine, Hokkaido University School of Graduate Medicine

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Other Title
  • β_2アドレナリン受容体遺伝子(Arg16Gly)多型が気管支喘息患者のβ_2刺激薬長期連用に与える影響
  • β2アドレナリン受容体遺伝子(Arg16Gly)多型が気管支喘息患者のβ2刺激薬長期運用に与える影響
  • ベータ2 アドレナリン ジュヨウタイ イデンシ Arg16Gly タケイ ガ キカンシ ゼンソク カンジャ ノ ベータ2 シゲキヤク チョウキ ウンヨウ ニ アタエル エイキョウ

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Abstract

Background: The coding region variant ArglGGly at the β_2-adrenoceptor gene (ADRB2) is functionally relevant, and is common in Japanese. Longer term clinical responses to short-acting and longacting β_2 agonists have been influenced by the Arg16Gly polymorphism. The purpose of the present study is to assess the clinical effects of real life usage of β_2-agonist (long-acting β_2-agonist, regular use of short-acting beta2 agonist, or oral β_2-agonist), as an add-on medication to inhaled steroids, in Arg/Arg and Gly/Gly patients with asthma. Methods: In a retrospective analysis of outpatient records, 27 patients with Arg/Arg and 35 patients with Gly/Gly had regular usage of β_2-agonist, whereas 37 patients with Arg/Arg and 29 patients with Gly/Gly had as-needed usage of β_2-agonist. During the follow-up periods at Hokkaido University Hospital, long term bronchodilator responses were assessed using 3 indexes: 1) improvement in FEV1 (ΔFEV1 [ml]), 2) ΔFEV_1/FEV_1 at an initial visit, 3) ΔFEV_1/predicted FEV_1. Results: In patients with Gly/Gly genotype, compared with as-needed usage of β_2-agonist, the regular usage of β_2-agonist was associated with greater improvement in FEV1 in every index (p=0.027-0.041). In contrast, in patients with Arg/Arg genotype, the regular usage of β_2-agonist showed no greater improvement in FEV_1 compared with as-needed β_2-agonist usage. Conclusion: Gly/Gly and Arg/Arg genotype responses to regular usage of β_2-agonists may differ in patients with asthma.

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