書誌事項
- タイトル別名
-
- RISK FACTORS FOR SIDE EFFECTS DUE TO THE USE OF ANTITUBERCULOUS DRUGS IN ELDERLY PATIENTS
- コウレイシャ オ タイショウ ト シタ コウケッカクヤク ノ フクサヨウ ハッセイ ニ カンヨスル キケン インシ ノ ケントウ
この論文をさがす
説明
[Purpose] This study was designed to evaluate incidence of clinical risk factors for side effects due to the use of antituberculous drugs.<BR>[Method] We re trospectively analyzed clinical records of 229 elderly patients with tuberculosis treated at our hospital. [Results] Temporary stop of antituberculous thera py proved to be needed because of side effects in 77 patients (33.6%). Adverse effects leading to drug discontinuation were liver dysfunction (15.7%), gastrointestinal dysfunction (7.0%), and skin rash (5.7%); other effects accounted for discontinuation in 5.2%. Risk factors for liver dysfunction according to Cox proportional hazards regression analysis were complications of HCV infection (hazard ratio or HR, 2.97; 95% confidence interval or Cl, 1.20 to 7.38; p = 0.019); hepaocellular injury present at admission (HR, 3.37; 95 % CI, 1.56 to 7.29; p=0.002); and dose of isoniazid (per mg/kg, HR, 1.40; 95% CI, 1.05 to 1.85; p=0.02). Body mass index was a risk factor for gastrointestinal dysfunction (per kg/m2, HR, 0.83; 95% Cl, 0.70 to 0.98; p =0.026).<BR>[Conclusion] Such identification of risk factors for side effects from antituberculous therapy in elderly tuberculosis patients would minimize adverse effects.
収録刊行物
-
- 結核
-
結核 83 (6), 457-463, 2008
一般社団法人 日本結核・非結核性抗酸菌症学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001205000953216
-
- NII論文ID
- 10025688681
-
- NII書誌ID
- AN00073442
-
- COI
- 1:STN:280:DC%2BD1cvlvVGqug%3D%3D
-
- ISSN
- 18842410
- 00229776
-
- NDL書誌ID
- 9547795
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDLサーチ
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可