Association between Periodontitis and Metabolic Syndrome Based on Examination of GCF Biomarkers

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  • NISHIGAKI Masaru
    Department of Dental Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • YAMAMOTO Toshiro
    Department of Dental Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • MIYATANI Fumitaro
    Department of Dental Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science Department of Epidemiology for Community health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • WATANABE Isao
    Department of Epidemiology for Community health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • MATSUI Daisuke
    Department of Epidemiology for Community health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • KURIYAMA Nagato
    Department of Epidemiology for Community health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • KANAMURA Narisato
    Department of Dental Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science

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Other Title
  • GCFバイオマーカー検査を用いた歯周病とメタボリックシンドロームとの関連性についての横断的研究
  • GCF バイオマーカー ケンサ オ モチイタ シシュウビョウ ト メタボリックシンドローム ト ノ カンレンセイ ニ ツイテ ノ オウダンテキ ケンキュウ

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Abstract

 We investigated the association between periodontitis and metabolic syndrome (MS) based on the examination of gingival crevicular fluid (GCF) biomarkers. <br> The community periodontal index (CPI) was examined to estimate the index of periodontitis. <br> Moreover, quantitive analysis of the GCF biomarkers was conducted using Perio-catcher (Ikagaku, Kyoto). <br> MS was judged according to the judging standard of the MS diagnostic-criteria examination committee. <br> The candidates were 1,119 persons. We examined the association between the presence or absence of periodontal pockets and expression of GCF biomarkers. <br> In addition, we examined the relationship between MS-associated parameters and CPI/GCF biomarkers using logistic regression analysis in the participants adjusted for age and sex. A high plasma glucose level was associated with Lf. BMI was associated with Lf and AT. The blood pressure was associated with CPI. However, there was no association between the parameters of lipids,the waist,MS, and CPI/GCF biomarkers. Among the subjects positive for MS-associated parameters, there were significant differences in BMI and lipids between subjects who were positive for 2 or more items on biomarker tests and those with negative reactions. <br> These findings revealed a significant correlation between the GCF biomarkers and MS-related index. <br> Furthermore, the possibility that the examination of GCF biomarkers may serve as an index useful for morbidity evaluation in periodontitis was suggested.

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