Fluoride in human milk

DOI
  • HARA Koji
    Department of Dental Health and Public Health, Kanagawa Dental College
  • HIRATA Yukio
    Department of Dental Health and Public Health, Kanagawa Dental College
  • TANI Takeshi
    Department of Dental Health and Public Health, Kanagawa Dental College
  • KIMOTO Kazunari
    Department of Dental Health and Public Health, Kanagawa Dental College
  • TANAKA Satoko
    Department of Dental Health and Public Health, Kanagawa Dental College
  • IIZUKA Yoshikazu
    Department of Dental Health and Public Health, Kanagawa Dental College

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  • 母乳中のフッ素に関する研究

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Abstract

A series of experiments were carried out to determine the fluoride content of human milk and dry milk (for formula feeding), day-today or time-course variations of the amount of fluoride contained in human milk, and fluoride excretion in human milk through ingestion of fluoride. Fluoride determination was done by microdiffusion technique with hexamethyldisiloxane and by pH/mV meter (Orion 801) with a fluoride sensitive electrode (Orion 96-09).<BR>The amount of fluoride contained in human milk was 3-7 ng/ml, which was mostly separated as compounds with a molecular weight under 500 through the ultrafiltration technique (Amicon, Diaflo membrane UM 05). Fluoride excretion in the human milk seemed to reflect fluoride ingestion to some extent, because it was increased 2 to 4 times by the ingestion of 5 or 10 mg of fluoride.<BR>On the other hand, the fluoride content in several kinds of dry milk was 50-80 ng/ml, when they were reconstituted with distilled water. In actual use, however, their fluoride content could be even higher because of the addition of fluoride from drinking water. Therefore, the fluoride intake by nursing infants from human milk is much lower than formula milk.

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