Relationship between Periodontal Biomarkers in Gingival Crevicular Fluid and Clinical Parameters Including Diabetes Mellitus and Kidney Function

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  • TAMAKI Naofumi
    Department of Preventive Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School
  • MATSUO Akira
    Kyoto City Kamigyou Dental Association
  • MIZUNO Akihiko
    Kyoto City Kamigyou Dental Association
  • MASAKI Humihiro
    Kyoto City Kamigyou Dental Association
  • NAKAGAWA Toru
    Kyoto City Kamigyou Dental Association
  • SUZUKI Masahiro
    Kyoto City Kamigyou Dental Association
  • FUKUI Makoto
    Department of Preventive Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School
  • TANIGUCHI Takashi
    Kyoto City Public Health Office
  • MIYAKE Tatsuro
    Kyoto City Public Health and Welfare Bureau Department of Preventive and Community Dentistry, Osaka Dental University
  • ITO Hiro-O
    Department of Preventive Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School

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Other Title
  • 歯肉溝液中の炎症関連バイオマーカーと糖尿病・腎機能マーカーとの関連性
  • シニク コウエキ チュウ ノ エンショウ カンレン バイオマーカー ト トウニョウビョウ ・ ジンキノウ マーカー ト ノ カンレンセイ

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A number of studies have reported the association between periodontal disease and diabetes mellitus or renal functions; however, few studies have addressed inflammatory biomarkers in gingival crevicular fluid (GCF). The aim of this cross-sectional study was to examine the relationship between biomarkers in GCF and diabetes mellitus or renal function markers. GCF samples were collected from participants of mass medical examinations and out-patients of a hospital with diabetes mellitus, and they underwent measurements for antitrypsin and lactoferrin. Multiple linear regression analyses were used to assess the associations between biomarkers in GCF and diabetes mellitus or the renal function markers. According to linear regression analysis after adjustment for the age and sex, all indexes of diabetic patients were significantly different from those of healthy participants (p<0.001). Diabetes mellitus or renal function markers had significant correlations with the inflammatory biomarkers in GCF. In conclusion, biomarkers in GCF were significantly correlated with biomarkers of diabetes mellitus or the renal function, and may be a useful health checkup tool for collaboration between medical and dental professionals.

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