糖尿病合併肺結核患者の末梢血白血球によるBCG食菌作用

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タイトル別名
  • Phagocytosis of BCG by Peripheral Blood Leucocytes of Tuberculous Patients Complicated with Diabetes Mellitus
  • トウニョウビョウ ガッペイ ハイ ケッカク カンジャ ノ マッショウケツ ハッ

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説明

The leucocyte phagocytosis of 3H-BCG was determined in vitro using peripheral blood taken from patients of pulmonary tuberculosis both with and without complication of diabetes mellitus, and the results were analyzed in relation to humoral factors. The following results were obtained: 1) Hyperglycemia (glucose>250mg/dl) did not affect the phagocytic activity, but stimulated exocytosis of bacteria which took place immediately after the phagocytosis. 2) High serum concentration of free fatty acids (>0.25mM) reduced the phagocytic activity. 3) Anti-mycobacterial antibody, essential for opsonization of BCG bacilli, was found sufficiently in all diabetic patients.<BR>In addition to the above clinical study, diabetic humoral abnormalities were reconstituted using normal blood, and a similar experiment was carried out. This gave the following findings: 1) High glucose concentration (500mg/dl) stimulated exocytosis of bacilli, which was accompanied with leucocyte damage. 2) Saturated fatty acids (1mM) inhibited phagocytosis. 3) Ketone bodies and acidosis did not influence the phagocytic function. 4) Insulin had no direct effect on the phagocytosis.<BR>The above observations seem to indicate that the humoral immunity is intact in diabetics but the serum abnormalities inherent to diabetes such as high blood glucose and high free fatty acids may interfere with the normal function of phagocytes which appears to be important in the effective defense against tuberculosis.

収録刊行物

  • 結核

    結核 55 (2), 31-41, 1980

    一般社団法人 日本結核病学会

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