EVALUATION OF JATA(12)-VARIABLE NUMBER OF TANDEM REPEATS AS A MARKER OF THE SOURCE OF TUBERCULOSIS OUTBREAKS IN OSAKA

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  • TAMARU Aki
    Department of Microbiology, Osaka Prefectural Institute of Public Health
  • WADA Takayuki
    Department of International Health, Institute of Tropical Medicine, Nagasaki University
  • IWAMOTO Tomotada
    Department of Microbiology, Kobe Institute of Health
  • HASE Atsushi
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences

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Other Title
  • JATA（12）-VNTR型別による結核集団発生事例の菌株異同調査
  • JATA(12)-VNTR カタベツ ニ ヨル ケッカク シュウダン ハッセイ ジレイ ノ キンカブ イドウ チョウサ

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Abstract

<p>[Objectives] To evaluate the usefulness of the JATA (12)-variable number of tandem repeats (VNTR) system for identifying the source of Mycobacterium tuberculosis outbreaks. [Design] JATA(12)-VNTR genotyping was performed on M.tuberculosis isolates from a total of 206 patients in whom group infection was confirmed by epidemiological studies ("group infection"), as well as from 64 patient clusters in whom group infection was suspected but not confirmed ("non-group infection"). The patients were diagnosed in Osaka Prefecture from April 1999 to December 2011. [Results] All isolates from the "non-group infection" patients showed a unique VNTR pattern, whereas isolates from 185 (89.9％) "group infection" patients showed a common and group-specific JATA (12)-VNTR pattern. However, single-locus variants were observed in 1 (1.6％) "non-group infection" case and in 21 (10.2％) "group infection" cases. [Conclusion] Tuberculosis in 248 (91.9％) of the 270 study patients could be correctly identified based on the genotyping of the isolates by using the JATA (12)-VNTR. If proper attention is paid to the single-locus variant, the JATA (12)-VNTR system would be a useful tool for identification of sources of tuberculosis outbreaks.</p>

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