Inhibition of the in vitro Formation of Calcium Phosphate Precipitates with Several Mouth Washes

HIDAKA Saburo, TONO Keiko, OKAMOTO Yoshizo

doi:10.5834/jdh.55.3_165

In order to study the possible influences on oral calcium phosphate precipitation (calculus formation, remineralization of enamel), 9 kinds of commercial mouth washes were tested using a pH drop method that measured in vitro formation of calcium phosphate precipitates. All these mouth washes claimed to offer one to three of the following functions or characteristics : cleaning, bacteriostatic, bacteriocidal, anti-inflammatory, anti-halitosis, and wetness. The order of most inhibiting toward calcium phosphate precipitation to least for the mouth washes tested was as follows : Hi-zac^[○!R], ConCool F^[○!R], Mondahmin^[○!R], GUM^[○!R], Renovigo^[○!R], Listerine^[○!R], 1/15 Isodine gargle^[○!R], 1/50 Neostelin green^[○!R], Kinusui^[○!R]. The mouth washes results were then compared with etidronate (an anticalculus agent), at a concentration range of 10〜60μM. When plotted on a graph alongside etidronate, the mouth washes results were level to or below the curve of the inhibiting effects of etidronate. Although Hi-zac^[○!R] contained two constituents with stimulatory effects, overall it displayed the strongest inhibiting influence. From these results, it is suggested that the divers effects of mouth washes could be anti-calculus and anti-remineralization of enamel. Therefore, it must be considered that some anti-calcification might occur when these products are used orally.

Inhibition of the in vitro Formation of Calcium Phosphate Precipitates with Several Mouth Washes

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