抗結核剤耐性化の要因(3)

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書誌事項

タイトル別名
  • FACTORS RELATING TO THE INCIDENCE OF DRUG RESISTANCE FOR ANTI-TUBERCULOSIS DRUGS DURING C H EMOTHERAPY (3)
  • コウケッカクザイ タイセイカ ノ ヨウイン 8 ショカイ チリョウ ノ ケイカ ト タイセイキン シュツゲンリツ
  • Relationship between the Incidence of Drug Resistance and the Course of Original Treatment
  • 初回治療の経過と耐性菌出現率

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説明

In order to clarify the relationship between the appearance of drug resistant tubercle bacilli and the effect of chemotherapy in the course of the disease, the clinical course of 123previously un-treated tuberculosis patients receiving triple drug combination therapy with SM, PAS and INH were analysed.<BR>The drugs analyse d here were SM, PAS and INH and the strains were difined as resistant if there were equal growths of tubercle bacilli on culture media containing 10 mcg SM, 1 mcg PAS or 0.1mcg INH.<BR>The analysis was performed on the following three groups of patients.<BR>Group A: 26 cases in which the tubercle bacilli were negative at the start of original treatment or converted to negative within 3 months, attaining therapeutic target, though aggravation occurred after cessation of original treatment. The susceptibility of the bacilli at the end of original treatment was substituted by the finding at the time of aggravation. The mean duration of the primary chemotherapy in this group was 17.5 months.<BR>Group B: 55 cases in which the tubercle bacilli were negative or con v erted to negative within 3 months but pulmonary resection was performed. The susceptibility of bacilli was measured with the bacilli obtained from resected lungs. The mean duration of chemotherapy before operation in this group was 10.4 months.<BR>Group C: 42 cases in which the tuberc l e bacilli was positive after 6 months chemotherapy. The mean duration of chemotherapy of this group was 12.5 months. The results obtained were as follows:<BR>1) The incidence of drug resistant ca s es were 19.2% in group A, 64.4% in group B and 83.3% in group C.<BR>2) The incid e nce of drug resistant cases was 19.2% when the course of bacteriological findings and that of chest roentgenogram were both excellent, 65.5% when the course of bacteriological finding was good but chest roentgenological finding did not improve, 72.7%when tubercle bacilli did not convert to negative but chest roentgenogram improved, 95.0%when the course of both bacteriological and roentgenological findings were poor.

収録刊行物

  • 結核

    結核 46 (6), 191-195, 1971

    一般社団法人 日本結核病学会

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