ANTI-TUBERCULOSIS ACTIVITY OF RIFAMPICIN FOR EXPERIMENTAL TUBERCULOSIS OF MICE

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  • マウス実験結核症に対するRifampicinの抗結核作用に関する研究
  • マウス ジッケン ケッカクショウ ニ タイスル Rifampicin ノ コウケッカク サヨウ ニ カンスル ケンキュウ

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Some reports have been presented on the effect of Rifampicin (RFP) for the experimental tuberculosis of mice, but few has been reported on Rifamycin-SV and desacetylrifampiein (Da-RFP).<BR>As the significant blood concentration of RFP is kept for a relatively long time, it is expected that RFP might be used on intermittent basis.<BR>In the present study, the survival rate of tu b erculous mice was compared among groups receiving oral administration of each drug (RFP, Da-RFP, Rifamycin-SV), and the effect of intermittent treatment by RFP was studied in comparison with that by INH.<BR>In the first experiment, the effect of RFP, Da-RFP and Rifamycin-SV was compared. Male mice of dd strain weighing about 25 g were used, and 0.1 ml (1 mg) of bacillary suspension (10 mg/ml) prepared from Sauton culture of Kurono strain was inoculated into tail vein of each mouse.<BR>Mice were divided into the following four groups. Each group consists of 9 or 10 mice.<BR>Group 1: Non-treated control<BR>Group 2: Treated with R F P, 0.5 mg every day orally<BR>Group 3: Treated with Da-RFP, 0.5 mg every d a y o rally<BR>Group 4: Treated with Rifamycin-SV, 0.5 mg every day orally<BR>Treatment was begun from sixth day after challenge, and was con t i nued for twenty days. Thereafter, no treatment was given and they were observed till forty-eighth day to know the survival rate of each group.<BR>Result is shown in Fig. All mice were dead till 25 th day in non-treated group and till 27 th day in Rifamycin-SV group, while 37% of mice survival till 48 th day in Da-RFP treated group, and all mice treated with RFP were alive till 48 th day.<BR>In the second experiment, the intermittent treatment of RFP was compared with that of INH. Male mice of dd strain weighing about 25 g were used, and 0.01 mg of bacillary suspension prepared from lyophilized bacilli of Kurono strain was inoculated in tail vein of mice.<BR>Mice were divided into nine groups.<BR>Group 1: Non-treated control<BR>Group 2: RFP 0.33 mg (17 mg/kg) every day orally<BR>Group 3: RFP 1 mg (50 mg/kg) twice a week orally<BR>Group 4: RFP 1 mg (50 mg/kg) once a week orally<BR>Group 5: RFP 2 mg (100 mg/kg) once a week orally<BR>Group 6: INII 0.2 mg (10 mg/kg) every day orally<BR>Group 7: INII 0.6 mg ( 30 mg/kg) twice a wee korally<BR>Group 8: INII 0.6 mg (30 mg/kg) once a week orally<BR>Group 9: INII 1, 2 mg (60 mg/kg) once a week orally

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