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- 野崎 昭雄
- 東京医科歯科大学第二内科
書誌事項
- タイトル別名
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- EXPERIMENTAL STUDIES ON EFFECT OF COMBINED USE OF 1314 TH AND INH TO INH-RESISTANT TUBERCLE BACILLI
- 1. Combination effect in liquid medium and in vertical diffusion method
- 第1報液体培地内および直立拡散法による併用効果の検討
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説明
We have repeatedly reported that in our clinical experience combined use of 1314Th and INH for patients having INH-resistant tubercle bacilli is more effective than the use of 1314Th alone.<BR>In the present study, experiments were conducted in order to confirm the combined effect of these drugs in vitro to INH-resitant tubercle bacilli.<BR>1) By using Dubos' liquid medium, a hundred combinations of 1314Th and INH were prepared, each containing different concentrations of these drugs. In these media, H Rv strain resistant to 50γ/ml/ of INH was cultured for two weeks. Consequently, when 2. 5γ/ml and 1γ/ml/ of 1314Th were contained in the medium, the favourable effect of the addition of INH was observed (Table 1).<BR>2) A similar effect was observed when Kirchner's medium was employed in place of Dubos' medium (Table 2).<BR>3) Combination effect of 1314Th and INH was examined by using Ogawa's vertical diffusion method. When INH was used in combination with 1314Th in such high concentrations as 25γ/ml/ and 50γ/ml, the resulting inhibitory zones were much higher than those observed when 1314 Th was used alone (Fig. 1, Table 3).
収録刊行物
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- 結核
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結核 39 (6), 217-222, 1964
一般社団法人 日本結核・非結核性抗酸菌症学会