1314THと1321THの試験管内抗結核菌力の比較

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タイトル別名
  • COMPARISON BETWEEN ANTITUBERCULOUS ACTIVITY OF α-ETHYL-THIOISONICOTINAMIDE (1314TH) AND α-N-PROPYLTHIOISONICOTINAMIDE (1321 TH) IN VITRO
  • 1314TH ト 1321TH ノ シケン カンナイ コウケッカクキンリョク ノ ヒカク

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As preliminary experiments, the influences of the following factors on the minimal inhibitory concentration of 1314 TH and 1321 TH to the growth of M. tuberculosis were examined: 1) pH of used media, 2) quantity and culture of incubated bacilli, 3) temperature and period of preservation of resistant media.<BR>1% Ogawa's egg med i a and Kirchner's semi-solid agar media were used, and 2 strains were used for experiments 1), 2) and 3). Following results were obtained.<BR>The minimal inhibitory concentration of both drugs for M. tuberculosis on 1% Ogawa's egg media was nearly equal at pH 6.8. They were also nearly equal on Kirchner's semi-solid agar media at pH 6.8.<BR>Antituberc u lous activity of both drugs tend to decrease at alkaline side on 1% Ogawa's egg media. On Kirchner's semi-solid media, the activity of 1314 TH and 1321 TH were 4 and 4∼8 times higher in acid side than in alkaline side.<BR>The minimal inhibitory concentration of b oth drugs for M. tuberculosis on both media was increased proportionally to the quantity and culture period of inoculated bacilli.<BR>The influence of preservation temperature of resistant media on the an t i tuberculous activity was as follows. The effects of both drugs were stable comparatively for long time on both media at 5°C. The higher the preservation temperature, the more sharp the decrease of effects. The decreasing speeds of both drugs were same at temperature over 30°C. The decrease of speed of 1314 TH was faster than that of 1321 TH at 20°C.<BR>After making these preliminary experiments, the antituberculou s activity of 1314 TH and 1321 TH in vitro were compared. H37Rv and 11 strains isolated from pulmonary tuberculous patients previously untreated with antituberculous drugs were used. The antituberculous activity of both drugs were nearly the same on the both media, if the factors influencing the minimal inhibitory concentration of antituberculous drugs to M. tuberculosis are fixed.

収録刊行物

  • 結核

    結核 46 (5), 137-152, 1971

    一般社団法人 日本結核病学会

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