HE EFFECTS OF ANTITUBERCULOSIS CHEMOTHERAPY <I>IN VITRO</I> UNDER VARIOUS CONDITIONS INADEQUATE FOR THE GROWTH OF TUBERCLE BACILLI

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  • MAEKAWA Nobuo
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • NAKANISHI Michiyasu
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • KAWAI Mitsuru
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • IKEDA Nobuaki
    First Department of Medicine, Chest Disease Research Institute, Kyoto University
  • NAKAI Hitoshi
    First Department of Medicine, Chest Disease Research Institute, Kyoto University

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Other Title
  • 結核菌の発育に不適当な条件と化学療法
  • ケッカクキン ノ ハツイク ニ フテキトウ ナ ジョウケン ト カガク リョウホウ 2 INH オヨビ SM ノ コウケッカクセイ ニ オヨボス PAS マエ ショリ ノ エイキョウ
  • II. Antituberculosis Activity of INH and SM <I>in vitro</I> after exposure to PAS
  • II.INHおよびSMの抗結核性に及ぼすPAS前処理の影響

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Bactericidal activity of INH and SM to Mycobacterium tuberculosis H37Rv after exposure to PAS were evaluated in vitro by means of Silicone-Coated Slide Culture Method (SSC).<BR>According to the results obtained, it is shown that bactericidal activity of IN H after exposure to PAS for a week, is lowered only in the series in which the culture media containing serial dilution of INH are not replaced, and it is not lowered in the series in which the culture media containing INH are replaced freshly once a week.<BR>As for SM, the diminishing trend of bactericidal activity is not observed in every series of the experiment.

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