Immunohistochemical and Clinical Features of Patients with Benign Middle Ear Tumors
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- Saruya Shoji
- Saruya ENT Clinic Department of Otolaryngology, Teikyo University School of Medicine
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- Nagamine Hisayo
- Department of Otolaryngology, Teikyo University School of Medicine
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- Komiya Takashi
- Department of Otolaryngology, Teikyo University School of Medicine
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- Ito Shigehiko
- Department of Otolaryngology, Teikyo University School of Medicine
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- Iino Yukiko
- Department of Otolaryngology, Jichi Medical University Omiya Medical Center
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- Kodera Kazuoki
- Department of Otolaryngology, Teikyo University School of Medicine
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- Imamura Tetsuo
- Department of Clinical Pathology, Teikyo University Hospital
Bibliographic Information
- Other Title
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- 中耳良性腫瘍の免疫病理組織像とその臨床的特徴
- チュウジ リョウセイ シュヨウ ノ メンエキ ビョウリ ソシキゾウ ト ソノ リンショウテキ トクチョウ
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Abstract
The middle ear is a rare site for benign tumors. We report six patients with benign middle ear tumors surgicaly removed : three with carcinoid, one with adenoma, and two with paraganglioma. These tumors showed similar histological features in trabecular and glandular architecture, so further immunohistochemical study was needed to make a definitive histopathological diagnosis. When we analyzed clinical features of patients diagnosed immunohistochemically, the differentiation of two patients with paraganglioma from the remaining four with adenomatous tumors such as adenoma and carcinoid was relatively easy from otomicroscopic findings and enhancement in temporal bone MRI. It was however difficult to differentiate patients with adenomatous tumors from each other because they induced similar clinical symptoms and showed similar findings in images. For a definitive diagnosis, it is necessary to conduct exploratory tympanotomy or removal of the tumors to obtain enough specimen for histological and immunohistochemical studies. Tumors induced no bone destruction or complications. We recommend staged operations for total removal of tumors and for good postoperative hearing.
Journal
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- Nippon Jibiinkoka Gakkai Kaiho
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Nippon Jibiinkoka Gakkai Kaiho 110 (5), 403-409, 2007
Japanese Society of Otorhinolaryngology-Head and neck surgery
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Details 詳細情報について
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- CRID
- 1390001205005395456
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- NII Article ID
- 10019727539
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- NII Book ID
- AN00191551
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- COI
- 1:STN:280:DC%2BD2szltVymuw%3D%3D
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- ISSN
- 18830854
- 00306622
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- NDL BIB ID
- 8837563
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed