Detection of FDG-PET and FDG-PET/CT in Head and Neck Squamous Cell Carcinoma

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  • Suzuki Hidenori
    Department of Head and Neck Surgery, Aichi Cancer Center Hospital Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University
  • Ogawa Tetuya
    Department of Head and Neck Surgery, Aichi Cancer Center Hospital
  • Terada Akihiro
    Department of Head and Neck Surgery, Aichi Cancer Center Hospital
  • Arima Shinobu
    Department of Otorhinolaryngology, Mie University Graduate School of Medicine
  • Ozawa Taijiro
    Department of Otorhinolaryngology, Nagoya City University School of Medicine
  • Suzuki Masahiro
    Department of Head and Neck Surgery, Aichi Cancer Center Hospital
  • Nakashima Tsutomu
    Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University
  • Tamaki Tuneo
    Department of Radiology, Nagoya PET Imaging Center
  • Nishio Masami
    Department of Radiology, Nagoya PET Imaging Center
  • Hasegawa Yasuhisa
    Department of Head and Neck Surgery, Aichi Cancer Center Hospital

Bibliographic Information

Other Title
  • 頭頸部扁平上皮癌におけるＦＤＧ‐ＰＥＴ，ＦＤＧ‐ＰＥＴ／ＣＴの診断能
  • 頭頸部扁平上皮癌における FDG-PET,FDG-PET/CTの診断能
  • トウケイブ ヘンペイ ジョウヒ ガン ニ オケル FDG PET FDG PET CT ノ シンダンノウ

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Abstract

We evaluated the accuracy of staging in 159 patients with head and neck squamous cell carcinoma (HNSCC) scanned by FDG-PET and 116 patients with the same cancer scanned by FDG-PET/computed tomography (CT). The accuracy was measured by comparing the FDG-PET/FDG-PET/CT findings at the primary tumor site, cervical node sites and distant metastatic sites with the clinical diagnosis. Especially, accuracy at cervical sites was evaluated from the screening point of view. Both examinations yielded an accuracy rate of more than 80% for each site, and a negative predictive value of more than 90% for the cervical sites. For the cervical sites, the positive predictive value (PPV) of FDG-PET was 78% and of FDG-PET/CT was 82%. When one cervical lymph node metastasis was detected by FDG-PET, the PPV was 63%, which appears to be comparatively low. Both examinations showed high accuracy for staging of HNSCC. In the near future, excellent screening examination might become possible with the spread of FDG-PET/CT. However, both examinations do not yield the direct image of the carcinoma itself, but only the status of glucose metabolism in the carcinoma. Care must always be exercised in the interpretation, as there are not a few false negative and false positive cases.

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