Two Cases of Radiation-induced Sarcoma after Radiation Therapy in Nasopharyngeal Carcinoma

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  • Okoshi Akira
    Department of Otolaryngology-Head & Neck Surgery, Tohoku University Hospital
  • Shiga Kiyoto
    Department of Otolaryngology-Head & Neck Surgery, Tohoku University Hospital
  • Sasaki Kazuha
    Department of Otolaryngology-Head & Neck Surgery, Tohoku University Hospital
  • Asada Yukinori
    Department of Otolaryngology-Head & Neck Surgery, Tohoku University Hospital
  • Nishikawa Hitoshi
    Department of Otolaryngology-Head & Neck Surgery, Tohoku University Hospital
  • Kobayashi Toshimitsu
    Department of Otolaryngology-Head & Neck Surgery, Tohoku University Hospital
  • Watanabe Mika
    Department of Pathology, Tohoku University Hospital

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Other Title
  • 上咽頭癌治療後に発生した放射線誘発肉腫の２例
  • ジョウイントウ ガン チリョウゴ ニ ハッセイシタ ホウシャセン ユウハツ ニクシュ ノ 2レイ

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We report two cases of radiation-induced sarcoma after chemoradiation therapy in nasopharyngeal carcinoma.<br>Case 1: A 40-year-old man developed a malignant peripheral nerve sheath tumor (MPNST) in the posterior floor of the nasal cavity 10 years after treatment for nasopharyngeal cancer. Case 2: A 64 year-old man developed a malignant fibrous histiocytoma (MFH) of the lower gum 10 years after treatment of nasopharyngeal cancer. Despite radical surgery, the man with MPNST had a recurrent tumor and died of the disease.

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