STUDIES ON THE LIPID METABOLISM IN THE COCHLEA

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  • NISHIMURA HIDEO
    Department of Otolaryngology, Kyoto Prefectural University of Medicine

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  • か牛脂質代謝に関する研究　Ｉ　　オートラジオグラフィー的研究
  • カタツムリ シシツ タイシャ ニカンスルケンキュウ 1 オートラジオグラフィー
  • オートラジオグラフィー的研究

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Abstract

The lipid metabolism in the guinea pig cochlea was studied by means of autoradiography with 3H-glycerol. Following results were obtained.<br>1) In this autoradiographic study, the most heavily labelled cells were the outer hair cells, especially intensive along the cell membrane, where there were the sheets of endoplasmic reticulum (subsurface cisterna).<br>2) In the hair cells the radioactivity increased gradually as the apex was approached, but in the other cells this longitudinal gradient was not seen.<br>3) Kanamycin depressed the incorporation of 3H-glycerol into the hair cells, especially outer hair cells. These results, together with the results obtained by biochemical and histochemical studies (ref. 2nd report), will be discussed in 2nd report.

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