糖代謝よりみたカナマイシ難聴の発現機序

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  • 橘正 芳
    京都府立医科大学耳鼻咽喉科学教室

書誌事項

タイトル別名
  • ON THE MECHANISM OF KANAMYCIN OTOTOXICITY(II)
  • 糖代謝よりみたカナマイシン難聴の発現機序
  • トウ タイシャ ヨリ ミタ カナマイシン ナンチョウ ノ ハツゲン キジョ
  • ALTERATION OF GLUCOSE METABOLISM IN COCHLEA AND KIDNEY

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Effect of intramuscular injection of kanamycin(KM)(400mg/kg, for 10 successive days) on glucose metabolism in the cochlea, kidney, liver and brain of the guinea pig was investigated. <br>The results obtained were as follows: <br>(1) Histological studies demonstrated morphological damages occurring in hair cells of the organ of Corti, especially outer hair cells on basal end(hook), and proximal tubules of the kidney. <br>(2) Biochemical studies revealed that in the organ of Corti and kidney, activities of hex-okinase and phosphofructokinase, regulatory enzymes of the activity of anaerobic glycolysis were reduced significantly, whereas those of glucose 6-phosphate dehydrogenase and 6-phosph-ogluconate dehydrogenase, regulatory enzymes of the activity of hexosemonophosphate pathway, (HMP) were not altered. <br>(3) Histochemical studies demonstrated that the activity of succinate dehydrogenase, regu-latory enzyme of the activity of TCA cycle, was reduced in the organ of Corti and the tubule of the kidney, respectively. <br>(4) The conversion of glucose into CO2 via glycolysis and TCA cycle was significantly inhibited in the cochlea and kidney and this change was not compensated by HMP. <br>(5) The formation of oto- and nephro-toxic effects of KM may he explainable at least in part by these changes in the glucose metabolism observed selectively in the organ of Corti and kidney. <br>(6) The present results suggest that the administration of drugs involved and/or related to the glucose metabolism such as pantothenic acid, thiamine, ATP or NAD may be useful for the treatment of deafness caused by the KM administration.

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