上顎癌三者併用療法の現況

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タイトル別名
  • COMBINED THERAPY OF SURGERY, RADIOTHERAPY AND CHEMOTHERAPY ON CANCER OF THE MAXILLARY SINUS
  • 上顎癌三者併用療法の現況--非動注66例の検討
  • ジョウガクガン サンシャ ヘイヨウ リョウホウ ノ ゲンキョウ ヒ ドウチュウ
  • A REPORT OF 66 CASES TREATED BY THE APPLICATION OF ANTICANCEROUS OINTMENT

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Since1963, the combination of surgery, radiotherapy, and chemotherapy was used for malignant tumours of the paranasal sinuses. This method reduced the rate of local recurrences and improved survival rate. Maxillary resection has not been performed even on the advanced cases since August 1965.<br>At present, to eradicate the cancer without excessive destruction of structures and functions, irradiation (average 800 rad), maxillary antrotomy and tumour removal, regional application of anticancerous ointment following day-by-day removal of necrotic tissue are our routine treatment even for the advanced cases.<br>In this paper, recent 66 cases, treated with this therapeutic regimen, were compared with 45 cases treated by arterial infusion of 5-FU and BUdR.<br>The conclusions are as follows;<br>1. The planning of treatment in the combined therapy on the cancer of the maxillary sinus should be determined according to clinical findings in each case. Antrotomy and tumour removal, repetitive removal of the necrotic tissues were performed with regional application of anticancerous ointment. As the result, arterial infusion of the anticancer drugs is now not necessary and average irradiation dosis have decreased to 800 rad in most cases.<br>2. In non-infused group, the residual tumour or to recurrence was successfully treated by the removal of the lesion.<br>3. In some cases, further irradiation under inhalation of the mixed gas (5 percent CO2 and 95 percent 02) and removal of the necrotic tissues were performed. Thus, in most patients preservation of the eyes, the palate, and the skin of the cheek were possible.

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