CELL-MEDIATED IMMUNE RESPONSE IN HUMAN PALATINE TONSILS

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  • SUENO KOHEI
    Department of Otorhinolaryngology, Nihon University School of Medicine

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  • ヒト口蓋扁桃における細胞性免疫応答
  • ヒト コウガイ ヘントウ ニ オケル サイボウセイ メンエキ オウトウ

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Abstract

The present work was undertaken in an attempt to elucidate cell-mediated immune response in human palatine tonsils. Using the tonsils extirpated from patients with tonsillar diseases such as chronic tonsillitis, habitual angina and tonsillar hypertrophy, the cell-free supernatants of ton-sillar lymphocyte cultures with diphtheria toxoid (DT) or streptolysin 0 (SLO) were prepared by the method described by Dumonde et al. The lymphokine capacities of the culture supernata-nts to exert cytotoxicity and cloning inhibition on Chang's human liver cells as well as migration inhibition of peripheral blood leucocytes were investigated.<br> The results obtained were summarized as follows: i) The culture supernatants of DT-stimulated tonsillar lymphocytes from patients showing positive reaction of Moloney's test, exhibited much greater activities of lymphokines such as lymphotoxin, cloning inhibitory factor, migration inhibitory factor than those from the negative individuals. 2) The majority of the culture supernatants from SLO-stimulated tonsillar lymphocytes sho-wed remarkable activities of three lymphokines. However, those lymphokine activities of each culture supernatant were not always in parallel with the titers of antistreptolysin 0 (ASO) in the corresponding patients' sera. From the above-mentioned findings, it was ascertained that the human palatine tonsils take part in cell-mediated immune response to regional or non-regional antigenic stimuli as well as in antibody-mediated immunity.

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