INFLUENCE OF LONG-TERM REPEATED ROTATOSTIMULATION ON LATERAL SEMICIRCULAR CANALS

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  • KIMURA NORIKO
    Department of Otolaryngology, Hirosaki University, School of Medicine

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  • 長時間反復回転刺激の水平半規管膨大部稜に及ぼす影響に関する実験的研究
  • チョウジカン ハンプク カイテン シゲキ ノ スイヘイ ハンキカン ボウダイブ

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Description

Sixty five guinea pigs were used to investigate the influence of rotatostimulation on the lateral crista ampullaris.<br>After repeating the turning of cupulometric mode (terminal turning velocity of 180°/sec) for 24 or 72 hours, caloric test revealed the severer functional disorder in the lateral semicircular canal of the ampullopetal side than the ampullofugal side and most of these changes occured within 24 hours.<br>On the other side, the morphological change of the crista ampullaris of ampullopetal side was compared with that of ampullofugal side by using light microscope, scanning and transmission electron microscope. In a group stimulated for 24 hours, damage was not clear and the difference between the ampullopetal side and the ampullofugal side was not observed. In a group stimulated for 72 hours, local damages were dominant in the central part of the crista which had a tendency to extend towards the planum semilunatum according to increment of changes. In this area, not only disappearance of the kinocilium but incomplete or complete loss of the stereocilia were observed. And degeneration of mitochondria was found especially in the upper part of sensory cells, but changes in the lower part of cells and nerve endings could not be found.<br>These findings were more remarkable in the ampullopetal side than in the ampullofugal side, and suggested the predominant effect of ampullopetal endolymphatic flow.

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