書誌事項
- タイトル別名
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- Two Cases of Intractable Malignant External Otitis with Skull Base Osteomyelitis Alleviated by Intraarterial Antibiotic Administration
- コウキンヤク ドウミャク チュウシャ ガ ソウコウ シタ トウガイテイ コツズイエン ガッペイ アクセイ ガイジドウエン ノ 2レイ
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Malignant external otitis (MEO) is a devastating external auditory canal infection usually occurring in the elderly with diabetes. MEO often progresses to potentially lethal skull base osteomyelitis (SBO) complications such as meningitis or multiple cranial nerve palsies. Poor vascularity in affected tissue due to diabetic microangiopathy and Pseudomonal infection is thought responsible for refractory infection. We conducted intraarterial antibiotic infusion (IA) in the external carotid artery of two subjects with intractable MEO deteriorating after long-term intravenous antibiotic administration with surgical debridement. IA raised the antibiotic concentration in infectious tissue. Clinical MEO manifestation was relieved just after starting IA, and IA therapy was followed by additional long-term intravenous and oral antibiotic administration, dramatically improving MEO while leaving only minimal infection at the skull base. These results demonstrate IA effectiveness in treating refractory MEO.
収録刊行物
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- 日本耳鼻咽喉科学会会報
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日本耳鼻咽喉科学会会報 113 (11), 851-855, 2010
一般社団法人 日本耳鼻咽喉科頭頸部外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001205011449856
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- NII論文ID
- 10029380510
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- NII書誌ID
- AN00191551
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- COI
- 1:STN:280:DC%2BC3M%2FmtVSitg%3D%3D
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- ISSN
- 18830854
- 00306622
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- NDL書誌ID
- 10912366
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- PubMed
- 21174732
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可