Efficacy of Early Combined High-dose Steroid+PGE1 Treatment for Sudden Deafness

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  • 突発性難聴に対するステロイド大量・PGE1併用療法の早期治療開始による効果
  • トッパツセイ ナンチョウ ニ タイスル ステロイド タイリョウ ・ PGE1 ヘイヨウ リョウホウ ノ ソウキ チリョウ カイシ ニ ヨル コウカ

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The efficacy of combined high-dose steroid and PGE1 treatment initiated immediately after the onset of sudden deafness was analyzed with the outcome of 174 patients begun on treatment within 7 days of the onset of sudden deafness.<br> Four potential prognostic factors (days from onset to treatment, age, initial hearing level, presence of vertigo) and hearing outcome were examined with a multiple logistic regression analysis. Days from onset to treatment and age significantly correlated with hearing improvement.<br> The efficacy of the treatment of patients begun on treatment within 3 days of the onset was significantly better than that of patients on treatment 4-7 days after the onset (p<0.001). In the examination of patients younger than 50 years, the efficacy of the treatment of patients begun on treatment within 3 days of the onset didn't differ significantly from that of patients on treatment 4-7 days after the onset. On the other hand, in the examination of patients aged 50 years and older, the efficacy of the treatment of patients begun on treatment within 3 days of the onset was significantly better than that of patients on treatment 4-7 days after the onset (p<0.001).<br> These results suggest that significant efficacy may be expected from the combined high-dose steroid+PGE1 treatment, if its use is started within 7 days of the onset of sudden deafness, and started within 3 days of the onset of sudden deafness in patients 50 years old and older.

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