Treatment of Vocal Fold Paralysis by Collagen Injection : Long-term Results

Kimura Miwako, Nito Takaharu, Imagawa Hiroshi, Tayama Niro

doi:10.2468/jbes.59.304

Bibliographic Information

Other Title

一側声帯麻痺症例に対する声帯内コラーゲン注入術長期経過の検討
イッソクセイタイマヒショウレイニタイスルセイタイナイコラーゲンチュウニュウジュツチョウキケイカノケントウ

Search this article

Abstract

Material for injection into the vocal folds must be injectable, long-lasting, and well tolerated by the host. Although many materials have been used, including silicone, collagen, fat and fascia, none have successfully met all criteria. Bovine collagen was a useful and easy therapy for glottic insufficiency; however, problems of resorption of injected collagen, allergic reaction and the possibility of rejection limited its use. We performed 121 collagen injections from January 1990 to December 2005 for unilateral vocal fold paralysis. 39 cases treated by collagen over a 2-year period were reviewed for assessment of long-term effects on phonation. No long-term local or systemic reaction to the collagen was seen. The median preoperative maximum phonation time (MPT) and mean flow rate (MFR) improved after collagen injection and the improvement was maintained during the 2-year follow-up term. Preoperative evaluation of voice between the over-2-years follow-up group and the under-2-years follow-up group did not show any statistically significant differences. The long-term results have proved satisfactory.

Journal

Nihon Kikan Shokudoka Gakkai Kaiho

Nihon Kikan Shokudoka Gakkai Kaiho 59 (3), 304-310, 2008

The Japan Broncho-esophagological Society

Keywords

Details 詳細情報について

Export