A Model for Acid Exposure using Trachea Excised from a Guinea Pig

DOI Web Site 1 Citations 16 References
  • Miwa Masato
    Department of Otolaryngology, Koshigaya Hospital, Dokkyo Medical University
  • Yamaguchi Shintaro
    Department of Otolaryngology, Koshigaya Hospital, Dokkyo Medical University
  • Nakajima Noriyuki
    Department of Otolaryngology, Koshigaya Hospital, Dokkyo Medical University
  • Murakami Atsushi
    Department of Otolaryngology, Koshigaya Hospital, Dokkyo Medical University
  • Watanabe Kensuke
    Department of Otolaryngology, Koshigaya Hospital, Dokkyo Medical University
  • Kouyama Kenya
    Department of Respiratory Medicine, Koshigaya Hospital, Dokkyo Medical University
  • Ichiwata Toshio
    Department of Respiratory Medicine, Koshigaya Hospital, Dokkyo Medical University
  • Nagao Koshu
    Department of Respiratory Medicine, Koshigaya Hospital, Dokkyo Medical University

Bibliographic Information

Other Title
  • 気管の酸暴露モデルの作成とプロトンポンプインヒビターの効果の検討
  • キカン ノ サン バクロ モデル ノ サクセイ ト プロトン ポンプ インヒビター ノ コウカ ノ ケントウ

Search this article

Abstract

The pathophysiological condition of the mucosal epithelium with laryngopharyngeal reflux disease (LPRD) is still obscure. We attempted to make a model for acid exposure using a trachea excised from a guinea pig. We evaluated the electrical barrier function of this model using the Ussing chamber technique. First, we investigated the effect of apical acidity on the short-circuit current (SCC) of the tracheal model. From pH 2, SCC was significantly increased, which indicates impaired barrier function. The impaired barrier functions exposed by HCl were recovered after apical ZnCl2. In this model, lansoprazole had no effect on the impaired barrier function and pepsin had no effect on SCC. These findings help to provide a new strategy for LPRD therapy.

Journal

Citations (1)*help

See more

References(16)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top