Efficacy of Radiotherapy for Local Control of Hypopharyngeal Cancer<br>—The Difference between Radiation Alone and Concurrent Chemoradiotherapy—

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  • Nakahara Susumu
    Department of Otolaryngology-Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine
  • Yoshino Kunitoshi
    Department of Otolaryngology-Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Fujii Takashi
    Department of Otolaryngology-Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Uemura Hirokazu
    Department of Otolaryngology-Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Suzuki Motoyuki
    Department of Otolaryngology-Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
  • Nishiyama Kinji
    Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

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Other Title
  • 下咽頭癌原発巣に対する放射線治療の効果—特に放射線単独と化学放射線同時併用の違いについて—
  • 下咽頭癌原発巣に対する放射線治療の効果 : 特に放射線単独と化学放射線同時併用の違いについて
  • シタ イントウガン ゲンパツ ソウ ニ タイスル ホウシャセン チリョウ ノ コウカ : トクニ ホウシャセン タンドク ト カガク ホウシャセン ドウジ ヘイヨウ ノ チガイ ニ ツイテ
  • Efficacy of Radiotherapy for Local Control of Hypopharyngeal Cancer^|^mdash;The Difference between Radiation Alone and Concurrent Chemoradiotherapy^|^mdash;

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Abstract

Larynx preservation is one of the goals in hypopharyngeal cancer treatment. To achieve it, concurrent chemoradiotherapy (CRT) has been widely used in recent years, but radiotherapy alone (RT) also shows good potential in controlling the primary tumor in the T1-2 stage, suggesting that the difference between CRT and RT's effectiveness in local control is unclear. Here, we report on local control of 101 patients with hypopharyngeal cancer treated with RT (n=52) or CRT (n=49) in the 3 years from January 2007 to December 2009 at Osaka Medical Center for Cancer and Cardiovascular Diseases. For all patients, the 2-year recurrence-free local control rate was 69% with RT and 84% with CRT, thus showing no significant differences between them. Because all T4 cases (RT : 1 case, CRT : 4 cases) had a recurrence, we analyzed only T1-3 patients. The 2-year recurrence-free local control rate here was 70% with RT and 91% with CRT, showing a significant difference. That CRT's efficacy should be significantly better than RT's in the local control rate would seem to be true in cases of T1-3 (T3 in particular) in the T stage, cases of pyriform sinus in the subsite, and cases with preceding neck dissection. In addition, when high-dose cisplatin (goal : 80mg/m2×3 in total) is administered for CRT, results suggested that the local control rate would be worse if the total dose of cisplatin is under 160mg/m2.

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