喉頭異常時の気道壁の形態学的変化

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  • 菊池 恭三
    Department of Otolaryngology, Nihon University School of Medicine

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タイトル別名
  • Morphological Changes of the Structures in the Air-Way due to Laryngeal Diseases
  • コウトウ イジョウジ ノ キドウヘキ ノ ケイタイガクテキ ヘンカ

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Electron microscopy was used to study the morphological changes of the tracheal epithelia in the laryngeal carcinoma. Nine humen tracheae were used for this study. Under the local anesthesia, tracheotomy was performed and a piece of the tracheal wall was removed. The specimen was treated by usual way for fixation, decalcification and cutting, then the tracheal epithelia with special reference to the cilia of the ciliated cells were observed with the aid of transmission and scanning electron microscopy. The results obtained were as follows:<BR>1) The morphological changes of the tracheal cilia were compared with the clinical findingsrespectively. There were not always found on relation between serious grade of carcinoma and histological changes of the tracheal cilia.<BR>2) The first morphological change of the cilium was observed as partial swelling of the cilium. Thenarrangement of the cilia became irregular.<BR>3) When pathological changes of the cilia were increased, adhesion and collapse of the cilia were found.<BR>4) The author and his associates have investigated morphological changes of the tracheal walls due to air pollutants such as SO2, NOx, O3, exhaust gas of gasoline motor car and others. Comparison of their findings and the results of this study was performed. It was a striking feature that the findings due to air pollutants were almost the same as those of carcinoma. The results above mentioned suggest that effects of chemical stimulation such as air pollutants were similar in appearance to those of physical stimulation such as air way stenosis due to carcinoma.

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