A Study on Protease in Tracheobronchial Secretion

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  • 気管気管支分泌液の蛋白分解酵素に関する研究
  • キカン キカンシ ブンピエキ ノ タンパク ブンカイ コウソ ニカンスルケンキ
  • 4. The Occurrence of Protease Inhibitor in Tracheobronchial Secretion of Rats after the Infusion of Proteases into the Bronchus
  • 第4報 蛋白分解酵素の気管内投与によるラット分泌液中 Inhibitor の出現

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In previous papers, we reported that the plasminogen activator existed in the tracheobronchial secretion of normal rats, but the activities that inhibit urokinase, papain and trypsin were not found. On the other hand, it has been reported that a protease inhibitor with low molecular weight was found in the nasal secretion and tracheobronchial secretion of humans with acute inflammation of the respiratory tract. Hochstrasser et al. suggested that the protease inhibitor with low molecular weight originated from the plasma inter-α-trypsin inhibitor and a trypsin-like enzyme in the inflammatory locus might play an important role in the production of this inhibitor. In order to examine the occurrence of protease inhibitor in the tracheobronchial secretion of rats, some proteases were infused into the tracheobronchus and the inhibitory activity on proteases was detected in the secretion.<br>The results obtained were as follows:<br>1) The occurrence of inhibitory activity on urokinase, plasmin and trypsin was not found.<br>2) The occurrence of inhibitory activity on papain was evident.<br>From the results obtained, it was concluded that the inhibitor against papain (SH-protease) was induced by the infusion of papain.

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