HS 66 Tのヒト白血球よりのヒスタミン遊離抑制作用ならびに各種アレルギー性疾患における臨床効果についての検討

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  • Effect of HS 66 T on Antigen-induced Histamine Release from Human Leukocytes and the Treatment of the Various Allergic Disordors
  • HS66T ノ ヒト ハッケッキュウ ヨリ ノ ヒスタミン ユウリ ヨクセイ

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A study was made to investigate the effect of HS 66 T on both the antigen induced histamine release and the treatment of the various allergic disorders. The results were as follows.<br>1. Effect on antigen-induced histamine release from leukocytes of asthmatics.<br>a. Histamine release on challenge with house dust antigen was suppressed with dose response curve by addition of HS 66 T (6×10-6-6×10-4g/ml) in 6 asthmatics. (The percentage of mean inhibition rate was 71.0%.)<br>b. Histamine release on challenge with house dust and mite antigen was slightly suppressed by administration of HS 66 T (150mg/day, during 7 to 14 days) in 8 asthmatics. (The percentage of mean inhibition rate was 14.3%.)<br>2. Clinical effect on administration of HS 66 T in various allergic disorders.<br>Clinical effect on administration of HS 66 T (100 to 150mg/day, during 7 to 21 days) was investigated in the various types of asthmatics, allergic rhinitis and urticaria. HS 66 T was obviously effective in 2 cases of allergic rhinitis and one urticaria case. In 7 asthmatics, 3 favorable cases, 3 unfavorable cases and one aggravated cases were observed.

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