Cetuximab-Induced Interstitial Pneumonia in Head and Neck Carcinoma

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  • Takahashi Katsumasa
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Nishioka Yuki
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Ida Shota
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Kuwabara Yuki
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Takahashi Hideyuki
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Okamoto Ayako
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Murata Takaaki
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Shino Masato
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Nikkuni Osamu
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Kudo Takeshi
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Sakakura Kouichi
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Takayasu Yukihiro
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine
  • Chikamatsu Kazuaki
    Department of Otorhinolaryngology-Head & Neck Surgery, Gunma University School of Medicine

Bibliographic Information

Other Title
  • 頭頸部癌におけるセツキシマブによる間質性肺炎
  • トウケイブガン ニ オケル セツキシマブ ニ ヨル カンシツセイ ハイエン

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Description

<p>　A total of 88 patients with head and neck carcinoma treated with cetuximab (Cmab) between 2013 and 2016 were retrospectively reviewed, and drug-induced interstitial pneumonia (IP) occurred in 7 patients (8.0%). Four of the seven patients had severe IP (over grade 3 according to the Common Terminology Criteria for Adverse Events, CTCAE), and 3 of these patients died of respiratory failure. Forty-three patients showed complete or partial response to Cmab treatment, although 7 cases (16.3%) developed drug-induced IP. Moreover, 5 cases had received treatment by the same protocol, which consisted of repeated induction chemotherapy and bio-radiotherapy with Cmab. Forty-five patients showed stable or progressive disease, but none of these patients developed IP (0%). We suspected that the risk of Cmab-induced IP increased, when the Cmab therapy was high-intensity and had good therapeutic effects.</p>

Journal

  • Nippon Jibiinkoka Gakkai Kaiho

    Nippon Jibiinkoka Gakkai Kaiho 120 (12), 1467-1472, 2017

    Japanese Society of Otorhinolaryngology-Head and neck surgery

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