遺伝と呼吸器疾患

DOI PubMed 被引用文献1件

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  • Genetics and respiratory diseases.

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Genetic and familial factors determining pathogenesis and pathophysiology were examined in patients with chronic bronchitis, bronchial asthma, sarcoidosis, and lung cancer and their healthy relatives.<br>Sons of bronchitics has smaller than average lung volumes though they were within normal limits, high permeability for CO, low airflow in the small airways, and lower leukocyte chemotaxis to C5a, while daughters did not show such trends. Mucociliary clearance in the hilar region was slower than controls in sons of bronchitics. In 35% of healthy siblings of asthmatics, airway reactivity to inhaled acetylcholine was increased. Hilar mucociliary clearance was also reduced in these siblings.<br>HLA DRw 52 was predominant (83.3%, p<0.002) and DRw 53 was infrequent (41.7%, p<0.007) in patients with sarcoidosis, occurrences in the controls being 50.9 and 71.9%, respectively.<br>In patients with lung cancer as well as their sons and daughters, serum selenium concentration was low compared to controls with no family history for cancer in first and second degree relatives; families of adenocarcinoma patietns having the lowest selenium among the families. Serum vitamin E level was also low in families of adenocarcinoma patiets. Occurrence of benzopyrene-induced sister chromatid exchange in peripheral lymphocytes was more frequent in families of lung cancer patients than families of non-cancer patients.

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