書誌事項
- タイトル別名
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- Changes in the Level of Thrombomodulin with Aging.
- ケンコウ セイジン ニ オケル カレイ ニヨル ケッチュウ thrombomo
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抄録
Thrombomodulin (TM) is a thrombin receptor on endothelial cells. When endothelial cells are damaged TM is degraded and released into the blood. We examined whether levels of TM in plasma reflect endothelial damage related to aging. We measured the TM level in samples of plasma from 93 healthy men aged from 22 to 81 years. None had hypertension, obesity, diabetes mellitus, or cardiovascular disease. The relationship between the level of TM (Y) and age (X) could be approximated by Y=0.176X+10.379, the correlation was significant (r=0.647, p<0.01). Basal levels of TM in subjects from 20 to 60 years old showed a gradual increase, that was not statistically significant. Basal concentrations of TM were significantly higher in the older subjects than in the younger subjects. The high levels of TM in the older subjects might reflect endothelial damage. In conclusion, a high TM level in plasma may be a sign of endothelial damage related to aging.
収録刊行物
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- 日本老年医学会雑誌
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日本老年医学会雑誌 33 (7), 512-517, 1996
一般社団法人 日本老年医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205019960576
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- NII論文ID
- 130003652234
- 10013848174
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- NII書誌ID
- AN00199010
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- NDL書誌ID
- 4022320
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- ISSN
- 03009173
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- PubMed
- 8890605
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可