百寿者の血清脂質組成とその特徴　低アポＢ血症と比較的ＨＤＬ２‐Ｃ高値　ＴＯＫＹＯ　ＣＥＮＴＥＮＡＲＩＡＮ　ＳＴＵＤＹ　Ｉ

DOI Web Site PubMed 被引用文献6件 参考文献22件

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タイトル別名
  • Lipid and Lipoprotein Profile of Japanses Centenarians. High Prevalence of Hypo .BETA. Lipoproteinemia.
  • ヒャクジュシャ ノ ケッセイ シシツ ソセイ ト ソノ トクチョウ テイ アポ
  • Hige Prevalence of Hypo β Lipoproteinemia
  • 低アポB血症と比較的HDL2-C高値 TOKYO CENTENARIAN STUDY I

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To study the relationship between lipids and longevity, we examined the level of serum lipids and apolipoproteins, and the susceptibility of low-density lipoprotein (LDL) to oxidation of 45 centenarians (15 men, 30 women, mean age 101.1±1.4) living in the Tokyo metropolitan area. The average levels of total cholesterol (TC), of LDL-C of high-density lipoprotein cholesterol (HDL-C), and of apolipoproteins A1 and B were significantly lower in centenarians than in healthy middle-aged controls. The frequency of hypobeta-lipoproteinemia (apoB<60mg/dl) in centenarians was almost ten times as high as in controls. The time course of copper-mediated LDL oxidation (assessed by monitoring 234nm diene absorption (lag time)) did not significantly differe between the two groups. Analysis of LDL subfractions by non-denaturated gradient-gel electrophoresis showed a predominance of large, buoyant LDL particles (pattern A) in 75%, and a predominance of small dense LDL particles (pattern B) in 25% of centenarians. We also assessed activities of daily living (ADL) and cognitive function in the centenarians. Centenarians were divided into two groups according to the median ADL score, and were classified into five groups with a scale clinical dementia. In subjects with good ADL scores, the mean concentration of HDL3-C was significantly higher than in those with poor ADL scores. Average levels of HDL-C were also significantly lower in subjects with moderate or severe dementia than in those with normal cognitive function. These findings suggest that centenarians have protective phenotypes of lipids and lipoproteins that protect them from ahteroscierosis.

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