Ｌｅｃｉｔｈｉｎ：ｃｈｏｌｅｓｔｅｒｏｌ　ａｃｙｌｔｒａｎｓｆｅｒａｓｅ（ＬＣＡＴ）活性の日内変動

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  • Diurnal changes in lecithin: Cholesterol acyltransferase (LCAT) activities and effects of oral fat load.
  • Lecithin cholesterol acyltransferase LC

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Six healthy volunteers were fed with the diet of same composition for two days. Thirthy gr of oil (P/S ratio: 1.2) were administered with each meal on the second day. Blood was collected at fasting, one and three hours after breakfast, and two and four hours after lunch and supper. The activities of LCAT and the levels of total cholesterol (TC), triglyceride (TG), free cholesterol (FC), free fatty acids (FFA), glucose (BG), and immuno-reactive insulin (IRI) in the plasma were estimated.<br>LCAT activities were 59.9±14.2 (mean±SD) nM/ml/hr on the first day and 58.4±13.3nM/ml/hr on the second day resepectively in the fasting state. No significant diurnal changes were observed in LCAT activities. Fat load did not affect the LCAT activities. Plasma TG levels reached the peak at two hours after lunch and decreased afterward. Fat load increases the postprandial TG levels in the plasma. However, the diural changing curves of plasma TG levels were same on both days. Plasma TC, FC and HDL-C levels stayed constant throughout the day and the effects of fat load were almost nil. Plasma FFA levels were highest in the fasting state. They decreased repidly after breakfast and increased slightly afterward. Fat load significantly increased plasma FFA levels after lunch and kept FFA at higher levels until the night. Diurnal changes of BS were relatively small and fat load did not affect BS levels. Plasma IRI levels stayed at high levels after lunch until the night and fat load did not affect plasma IRI levels.<br>Correlation coefficients between LCAT activities and other parameters mentioned above were calcluated. LCAT activities has positive correlations with TC (r=0.632, p<0.05), TG (r=0.793, p<0.01), FC (r=0.855, p<0.001) and HDL-C (r=0.577, p<0.05) in the fasting state, but had no correlation with FFA, BS and IRI. When correlation coefficients were calculated based on all data in both fasting and postprondial states, LCAT activities had positive correlations with TC (r=0.403, p<0.001), TG (r=0.508, p<0.001), FC (r=0.415, p<0.001), HDL-C (r=0.855, p<0.001), and FFA (r=0.266, p<0.02), but had no correlations with BS and IRI.

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