大気汚染の人肺えの影響に関する病理学的研究

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タイトル別名
  • STUDIES ON HISTOLOGICAL CHANGES OF HUMAN LUNGS AFFECTED BY AIR POLLUTION

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Relations between morphological changes and degrees of anthracosis in the human lungs were histologically examined in order to prove some hazardous effects of air pollution for the residents in the Osaka area.<br>Reid index and “mucous mucous gland ratio” of bronchial mucous gland are also comparatively studied. “Mucous gland ratio” is a ratio of mucous gland cell dimension per serous gland cell dimension, in the same bronchial mucous gland within a cross section of the large bronchus. This ratio is measured on the Linear Integration Method. Length of 16 parallel lines drawn on each mucous gland cell area and serous gland cell area are summed up. The total length across the mucous gland cell area is indicated as M and the total length across the serous gland cell area is indicated as S. Mucous gand ratio is indicated as M/S+M in this paper.<br>The results obtained are summarized as follows:<br>1. The degree of anthracosis in the lungs of men lived more than 10 years in the air polluted city is markedly higher than that of the residents in non-polluted cities.<br>2. The degree of anthracosis and M/S+M ratio increase as age advances. Reid index has no deffinite relations to the degree of anthracosis.<br>3. A relationship was obviously observed between the degree of anthracosis and squamous metaplasia of bronchial epithelial cells. Cellular infiltration within bronchial walls, hypeplasia of bronchiolar mucous cells and fibrosis of bronchial walls showed no relations with the degree of anthracosis.

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