Changes in the Level of Endothelin-1 with Aging.
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- Komatsumoto Satoru
- Ashikaga Red Cross Hospital
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- Nara Masaharu
- Ashikaga Red Cross Hospital
Bibliographic Information
- Other Title
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- 血しょうＥｎｄｏｔｈｅｌｉｎ‐１値における加齢の影響について
Abstract
Endothelin-1 (ET-1) is a potent and long-lasting vasoconstrictor peptide. In order to clarify the changes in the level of ET-1 with aging, we measured the ET-1 level in plasma by radioimmunoassay and used 74 healthy subjects including 61 males and 13 females, aged from 30 to 69, who were admitted in the health check center of Ashikaga Red Cross Hospital. None of them had risk factors related to hypertension, obesity, diabetes mellitus or cardiovascular disease. In the male group, the relationship between the level of ET-1 (Y) and age (X) was obtained as follows: Y=0.08857X+0.06363. The correlation between them was significant (γ=0.65894, p<0.05). In the female group also, the increased level of ET-1 (Y) with age (X) showed an excellent linear relationship (Y=0.163091X-4.23, γ=0.762, p<0.002). These studies demonstrated that the level of ET-1 increased in relation to aging and the increased ET-1 production with aging may be consistent with deterioration of endothelial function.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 32 (10), 664-669, 1995
The Japan Geriatrics Society