福岡県下在住の百歳老人（Ｃｅｎｔｅｎａｒｉａｎ）の研究　（第２報）　　血液生化学および内分泌学的検討成績

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タイトル別名
  • Studies on centenarians in Fukuoka prefecture. (II). Serum levels of biochemical components, lipids and pituitary, adrenal and gonadal hormones.
  • フクオカケンカ ザイジュウ ノ 100サイ ロウジン Centenarian
  • Serum Levels of Biochemical Components, Lipids and Pituitary, Adrenal and Gonadal Hormones
  • 血液生化学および内分泌学的検討成績

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The serum levels of biochemical components, lipids and pituitary, adrenal and gonadal hormones in 22 centenarians (3 males and 19 females) in Fukuoka prefecture were measured and compared with those in normal healthy individuals aged 20-90 years. The mean values of serum protein concentration and albumin/globulin ratio showed a gradual decrease with advancing age, while blood urea nitrogen (BUN) levels tended to increase slowly from 90 years of age. No significant differences in serum levels of creatinine, uric acid, glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) were observed between the centenarians and the control group aged 70-79 years, though serum lactic dehydrogenase (LDH) levels were significantly low in the female centenarians, not in the males, compared with the control group. In males, the serum levels of total cholesterol were significantly lower in the centenarian group than in the control group aged 70-79 years. The serum levels of triglyceride and high density lipoprotein-cholesterol showed no significant alterations with age in both sexes. The serum levels of apolipoprotein A-I and A-II showed a progressive decline with increased age. Serum luteinizing hormone (LH) levels increased from the 6th decade of life in both sexes, reached the peak values at the 8th decade in males and at the 7th decade in females, and declined thereafter. Conversely, in females, serum LH levels in the centenarians were significantly higher than those in the individuals aged 90-99 years. However, serum growth hormone (GH) levels showed no significant change in the males and females over 70 years of age. No aged-related alterations in the serum levels of prolactin (PRL) and thyroid stimulating hormone (TSH) were observed. Serum cortisol levels remained unchanged in advanced old age; however, serum dehydroepiandrosterone (DHEA) sulfate showed a gradual decline from 20 years of age, although there were no significant changes over 70 years in both sexes. In males, serum 17-hydroxyprogesterone and testosterone, which declined progressively from 60 years of age, showed no significant difference in the mean levels between the centenarians and the individuals aged 70-79 years.

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