Glucose Metabolism and Alzheimer's Dementia.
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- Itagaki Teruyuki
- Department of Internal Medicine, Yokufukai Geriatric Hospital
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- Itoh Yoshinori
- Department of Internal Medicine, Yokufukai Geriatric Hospital
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- Sugai Yuichi
- Department of Psychiatry, Yokufukai Geriatric Hospital
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- Suematsu Naomi
- Department of Pathology, Yokufukai Geriatric Hospital
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- Ohtomo Eiichi
- Department of Internal Medicine, Yokufukai Geriatric Hospital
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- Yamada Masahito
- Department of Neurology, Tokyo Medical and Dental University
Bibliographic Information
- Other Title
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- 糖代謝とアルツハイマー型痴呆について
- トウ タイシャ ト アルツハイマーガタ チホウ ニ ツイテ
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Description
Blood glucose levels are abnormally low in Alzheimer's dementia. We therefore examined glucose metabolism before death in relation to Alzheimer's dementia as determined at autopsy in 106 men and 161 women. (1) The mean age was 81.8±8.6 years for men and 85.8±7.9 years for women (p<0.001). The fasting plasma glucose level and hemoglobin Alc levels did not differ by sex. (2) Alzheimer's dementia was detected in 88 patients (25.5%). More women than men had the disease, but the difference was not significant. (3) Only 8.8% (3/34) of patients with diabetes mellitus had Alzheimer's dementia, as compared with 27.9% of patients without diabetes mellitus (65/233, p<0.03). (4) The fasting plasma glucose level was 89.9±13.4mg/dl in patients with Alzheimer's dementia and 102.9±34.5mg/dl in those without the disease. The hemoglobin Alc level was 5.7±0.8% in patients with Alzheimer's dementia and 6.4±1.5% in those without the disease. Both the fasting glucose level and hemoglobin Alc level were significantly lower in patients with Alzheimer's dementia than in those without the disease, p<0.01. These data suggest that the development of Alzheimer's dementia is suppressed by the high plasma glucose levels in patients with diabetes mellitus.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 33 (8), 569-572, 1996
The Japan Geriatrics Society
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Details 詳細情報について
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- CRID
- 1390001205022587008
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- NII Article ID
- 130003652249
- 10013851747
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- NII Book ID
- AN00199010
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- NDL BIB ID
- 4048066
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- ISSN
- 03009173
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- PubMed
- 8921693
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed