Expression of Decay-accelerating Factor on CD8-positive Lymphocytes as an Index of Aging and of Host Defense Function.
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- Fuchino Yasuhide
- First Department of Surgery, School of Medicine, Fukuoka University
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- Okada Noriko
- Department of Molecular Biology, Nagoya City University School of Medicine
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- Funabashi Katsuaki
- Choju Medical Institute, Noyori-Fukushimura Hospital
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- Otsuka Kichiro
- First Department of Surgery, School of Medicine, Fukuoka University
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- Tomita Akira
- First Department of Surgery, School of Medicine, Fukuoka University
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- Shinohara Tsurayuki
- First Department of Surgery, School of Medicine, Fukuoka University
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- Ikuno Toshihide
- Choju Medical Institute, Noyori-Fukushimura Hospital
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- Okada Hidechika
- Department of Molecular Biology, Nagoya City University School of Medicine
Bibliographic Information
- Other Title
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- 老化と生体防御能の指標としてのリンパ球上補体制御膜糖蛋白群の発現動態
- ロウカ ト セイタイ ボウギョノウ ノ シヒョウ トシテノ リンパキュウジョウ
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Abstract
Decay-accelerating factor (DAF) is a membrane glycoprotein that prevents complement activation on blood cells. Among CD8+ T cells, DAF-negative cells can be distinguished from DAF-positive cells. We computed the proportion of DAF-negative CD8+ T cells in the peripheral blood of 59 normal healthy subjects, 27 to 93 years old, and analyzed the differences between subjects of different ages. The proportion of CD8+ T cells that were DAF-negative correlated significantly and positively with age. We also studied these lymphocytes in patients with cerebrovascular dementia, Alzheimer's dementia, cancer, rheumatoid arthritis and systemic lupus erythematosus. The proportion of CD8+ T cells that were DAF-negative did not correlate significantly with age in patients with cerebrovascular dementia, Alzheimer's dementia or cancer, but it correlated significantly and positively with age in patients with rheumatoid arthritis and in those with systemic lupus erythematosus. Therefore, healthy subjects and patients with various diseases can be classified according to age and to the proportion of CD8+ T cells that are DAF-negative. This proportion can then be used as an index of aging and of host defense function.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 33 (8), 580-585, 1996
The Japan Geriatrics Society
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Details 詳細情報について
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- CRID
- 1390001205023288704
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- NII Article ID
- 130003652246
- 10013851773
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- NII Book ID
- AN00199010
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- NDL BIB ID
- 4048068
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- ISSN
- 03009173
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- PubMed
- 8921695
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed