Clinico-pathological Evaluation of Leukoaraisosis in Alzheimer's Disease.
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- Ishijima Michiko
- Second Department of Internal Medicine, Nippon Medical School
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- Imazu Osamu
- Second Department of Pathology, Nippon Medical School
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- Kitamura Shin
- Second Department of Internal Medicine, Nippon Medical School
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- Terashi Akirou
- Second Department of Internal Medicine, Nippon Medical School
Bibliographic Information
- Other Title
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- アルツハイマー型痴呆患者にみられる脳室周囲白質病変についての臨床的および病理学的検討
- アルツハイマーガタ チホウ カンジャ ニ ミラレル ノウシツ シュウイ ハクシ
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Abstract
Patients with multi-infarct dementia often have periventricular low density lesions on computed tomography and periventricular hyper-intensity lesions on computed tomography and periventricular hyper-intensity lesions on magnetic resonance imaging. Hachinski called this condition leukoaraiosis and results of previous studies that in multi-infarct dementia leukoaraiosis correlates with cerebral hypoperfusion. Periventricular low-density lesions in the white matter also occur, but their origin and clinical significance insuch patients is unknown. We studied when these lesions develop in patients with Alzheimer's dementia, and whether their presence correlates with clinical findings and cerebral blood flow. The subjects were 37 patients with a probable diagnosis of Alzheimer's dementia, as based on the Neuroepidermilogy Branch of the National Institute of Neurological Disorders and Stroke and the Alzheimer's disease and Related Disorders Association system. Autopsy findings were also available for 2 patients. Patients at higher Functional Assessment Staging of Senile Dementia of Alzheimer Type stages had more extensive periventricular low-density lesions. Patients with the lesions were more likely to have grasp reflex and sucking relex. Blood flow to the frontal and parietal cortices was significantly less in patients with the lesions than in those without the lesions. Neither of the 2 autopsies cases yielded evidence of arteriolosclerosis. Periventricular low-density lesions in Alzheimer's dementia may be closely associated with a degenerative process different from that seen in multi-infarct dementia.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 33 (10), 744-753, 1996
The Japan Geriatrics Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205023365632
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- NII Article ID
- 130003652175
- 10013852055
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- NII Book ID
- AN00199010
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- NDL BIB ID
- 4078831
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- ISSN
- 03009173
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- PubMed
- 8958737
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed