Multicenter Prospective Survey of Prognosis of Hypertensive Elderly Outpatient under Antihypertesive Treatment. Morbidity and Mortality of Cardiovascular Diseases and Cancer.
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- Ogihara Toshio
- Department of Geriatric Medicine, Osaka University Medical School
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- Morimoto Shigeto
- Department of Geriatric Medicine, Osaka University Medical School
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- Nakahashi Takeshi
- Department of Geriatric Medicine, Osaka University Medical School
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- Hiwada Kunio
- Second Department of Internal Medicine, Ehime University School of Medicine
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- Matsuoka Hiroaki
- Department of Cardiology Medicine, Dokkyo Medical University
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- Matsumoto Masayuki
- Department of Gerontology, Kanazawa Medical University
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- Shimamoto Kazuaki
- The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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- Onchi Yasuyoshi
- Department of Geriatrics, Faculty of Medicine, University of Tokyo
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- Abe Isao
- Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- Mikami Hiroshi
- Department of Community Health Nursing, Osaka University Medical School
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- Ishimitsu Toshihiko
- Department of Medicine, National Cardiovascular Center
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- Kohara Katuhiko
- Department of Geriatric Medicine, Ehime University School of Medicine
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- Takizawa Satoshi
- Department of Gerontology, Kanazawa Medical University
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- Takasaki Mikihiro
- Department of Gerontology, Kanazawa Medical University
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- Masuda Atushi
- The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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- Munehira Junnichi
- Department of Gerontology, Kanazawa Medical University
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- Eto Masato
- Department of Geriatrics, Faculty of Medicine, University of Tokyo
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- Takagawa Yoshitoki
- The Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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- Kiyohara Yutaka
- Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- Ibayashi Seturou
- Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- Nakamura Toshiko
- Department of Medicine, National Cardiovascular Center
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- Fujishima Masatoshi
- Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
Bibliographic Information
- Other Title
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- 降圧薬療法下通院中の老年者高血圧患者の3年間予後に関する多施設調査 脳心血管疾患および悪性疾患の発症・死亡について
- コウアツヤク リョウホウ カツウイン チュウ ノ ロウネンシャ コウケツアツ カンジャ ノ 3ネンカン ヨゴ ニ カンスル タシセツ チョウサ ノウ シンケッカン シッカン オヨビ アクセイ シッカン ノ ハッショウ シボウ ニ ツイテ
- Morbidity and Mortality of Cardiovascular Diseases and Cancer
- 脳心血管疾患および悪性疾患の発症・死亡について
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Abstract
Although calcium-channel blockers and angiotensin-I-converting enzyme inhibitors are often used for treatment of hypertension in the elderly in Japan compared to those in the United States and in European countries, there have been few investigations on the prognosis of the elderly receiving these antihypertensive treatments. The Research Group for “Guidelines on the Treatment of Hypertension in the Elderly” collaborated with the Comprehensive Research Projects on Aging and Health group of the Ministry of Health and Welfare of Japan in performing a 3-year survey on the outcome of 700 hypertensive elderly outpatients (≥60 years) receiving treatment of antihypertensive drugs. Antihypertensive drugs including dihydropyridine-type calcium cannel blockers, beta blockers, angiotensin-I-converting enzyme inhibitors, diltiazem, diuretics and old-type antihypertensives (hydralazine, budralazine, and centrally acting drugs such as clonidine, methyldopa and guanabenz) were administered to 71.3%, 30.4%, 26.2%, 14.0%, 8.6%, and 6.4% of the 642 elderly patients surveyed for three years, at the time of registration, respectively. Morbidity and mortality rates of total cerebro-cardiovascular diseases, stroke, and heart diseases, were 27.6 and 7.81/1, 000 patient-years, 15.1 and 3.6/1, 000 patient-years, 10.4 and 4.2/1, 000 patient-years, respectively. These results were similar or even better than those of megatrials of antihypertensive treatments for elderly patients in Europe and United States. After adjustment for potential confounding factors, multiple logistic analysis revealed that a past history of ischemic heart disease, use of the old-type antihypertensive drugs, male gender, and diastolic high blood pressure were independent risk factors for the morbidity of cerebro-cardiovascular diseases taking the group of non-cerebro-cardiovascular disease as the reference group. We also identified 22 cases of newly occurred malignancies including 7 fatal cases. However, none of the antihypertensives was significantly related to the occurrence of malignancies. These results lead support to the tendencies in the use of antihypertensive drugs in Japan.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 36 (5), 342-352, 1999
The Japan Geriatrics Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205023420416
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- NII Article ID
- 10008484736
- 130003652503
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- NII Book ID
- AN00199010
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- NDL BIB ID
- 4823647
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- ISSN
- 03009173
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- PubMed
- 10466352
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed