脂肪組織の代謝に関する研究 (第1報)

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書誌事項

タイトル別名
  • Studies on Metabolism of Adipose Tissue-I
  • シボウ ソシキ ノ タイシャ ニ カンスル ケンキュウ 1 シボウ サイボウ ノ オオキサ ト ネンレイ , ヒマンド ト ノ カンケイ ニ ツイテ
  • with special reference to the Relation between Size of Eat Cells, Weight Index and Aging
  • 脂肪細胞の大きさと年令, 肥満度との関係について

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Information on the size and number of adipose tissue fat cells is of considerable interest in metabolic studies of obesity. Diameters of fat cells were measuered by the method of Björntorp with some modification. Adipose tissue, obtained by surgical operation or by percutaneous needle biopsy, was fixed in formaldehyde for 7 minutes. Thereafter, adipose tissue was frozen and sectioned by a microsome. Diameters of fat cells in a slice, floating in isotonic saline, were measuered under a microscope. In a given part of the slice, except perivascular region where small fat cells were found clusterring, 100 fat cells were measuered, avoiding any selection. Almost normal distribution of fat cell diameters was found by this method. The average error of this method for diameter was 7.2%. This method is less expensive and requires a smaller amount of tissue than the other method and appeared to be useful in clinical and metabolic studies. Adipose tissue samples, obtained from 15 patients at surgical operations, were analyzed by this method, revealing that the weight of fat cell correlated significantly with percent ideal body weight (p<0.01). However, difference could not be demonstrated in this correlation between the group over 60 yrs and the group under 60 yrs. Subjects expressing their obesity in their childhoods had smaller fat cells than those who had become obese in adult life, even though two groups showed almost similar weight index. This fact suggests that the obesity developed in childhood could be due to an increase in the number of fat cells with concomitant increase of cell size.

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