Creatinine clearance estimation in the elderly.

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  • Kato Akihiko
    Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital The 1st Department of Internal Medicine, Hamamatsu University School of Medicine
  • Fukayama Makiko
    Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
  • Inamatsu Takashi
    Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
  • Rikimaru Tooru
    Department of Nutrition, Tokyo Metropolitan Institute of Gerontology

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Other Title
  • 老年者におけるクレアチニンクリアランス推定式の検討
  • ロウネンシャ ニ オケル クレアチニン クリアランス スイテイシキ ノ ケン

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In 66 aged patients, with normal serum creatinine level (≤1.2mg/dl) and having underlying disease, the measured creatinine clearance (Ccr) value was compared with the predicted Ccr value. The best correlation was obtained by the formulae of Yasuda. In each group of bed-ridden patients, severe infection, and parenteral alimentation patients, the measured Ccr value was lowered about 80% in comparison with the predicted Ccr value. The simultaneously measured urinary 3-methylhistidine was also lowered. This estimated serum creatinine level tended to understimate renal insufficiency when accompanied by decreasing systemic muscle volume.

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