日本人の家族性高コレステロール血症の診断基準について

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  • Diagnostic Criteria for Familial Hypercholesterolemia in Japan
  • ニホンジン ノ カゾクセイ コウ コレステロール ケッショウ ノ シンダン キ

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Definite diagnostic criteria for familial hypercholesterolemia (FHC) have been established in the United States and Europian countries. However, it is uncertain whether the criteria are applicable for the diagnosis of FHC in Japan where the diet of the people is different from a conventional Western-type diet.<br>In this report we studied the serum lipids of 55 patients of FHC with tendon xanthomas or Achilles tendons of increased thickness. The results were as follows:<br>1) The serum cholesterol levels of FHC were between 255 and 908mg/dl (Mean±SEM, 385±14mg/dl).<br>2) The serum triglyceride levels of FHC were between 54 and 307mg/dl (Mean±SEM, 128±9mg/dl).<br>3) The low-density-lipoprotein cholesterol levels determined in 7 patients of FHC were between 226 and 360mg/dl.<br>4) From the above data, the diagnostic criteria for FHC are either i) hypercholesterolemia greater than 250 mg/dl with tendon xanthomas or Achilles tendons of increased thickness, or ii) hypercholesterolemia greater than 250mg/dl in a first-degree relative of FHC.

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