The Prophylactic Effect of Elastase Complex on Experimental Atheromatosis in Rabbits

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  • Fujishiro Noboru
    2nd Department of Internal Medicine, School of Medicine, University of Nagoya
  • Ohta Hideya
    2nd Department of Internal Medicine, School of Medicine, University of Nagoya
  • Kawashima Shiro
    2nd Department of Internal Medicine, School of Medicine, University of Nagoya
  • Miyoshi Shigefumi
    2nd Department of Internal Medicine, School of Medicine, University of Nagoya
  • Kawade Yoshihiro
    2nd Department of Internal Medicine, School of Medicine, University of Nagoya
  • Machida Motomi
    2nd Department of Internal Medicine, School of Medicine, University of Nagoya

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Other Title
  • 家兎実験的粥状動脈硬化症に対するエラスターゼの予防効果について
  • カト ジッケンテキガユジョウ ドウミャク コウカショウ ニ タイスル エラスターゼ ノ ヨボウ コウカ ニ ツイテ

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The prophylactic effect of orally administered elastase complex on cholesterol-induced experimental atheromatosis in rabbits was studied during the 21-week period. The concentration of cholesterol in the serum was significantly depressed by the administration of elastase complex. The contents of cholesterol, both free and total, were also reduced in the thoracic aorta.<br>In the liver, however, the contents of cholesterol were not affected. The degree of atheromatosis of the coronary arteries was not affected.<br>The conclusion may be drawn that the effect of elastase-complex to atheromatosis is due to its lipolytic activity.

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