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- Kawaguchi Hiroshi
- Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo
Bibliographic Information
- Other Title
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- 高齢者の健康増進におけるトランスレーショナルリサーチ―エビデンスに基づく高齢者の健康増進への戦略―６．加齢に伴う骨粗しょう化の分子メカニズム
Abstract
Bone loss by ageing has been investigated from standpoints of systemic abnormality and some deficiency in osteoblastic bone formation. This seminar summarizes the involvements of a key molecule of adipocytic differentiation PPAR-gamma, essential IGF-I signaling molecules IRS-1 and IRS-2, and an anti-aging gene klotho in the pathophysiology of age-related osteoporosis.
Journal
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- Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
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Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 41 (6), 612-615, 2004
The Japan Geriatrics Society