Myeloma Precursor Cells

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  • IWATO Koji
    Department of Internal Medicine, National Ohtake Hospital
  • KAWANO Michio M.
    Department of Internal Medicine, Research Institute for Nuclear Medicine and Biology, Hiroshima University

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Other Title
  • 骨髄腫前駆細胞
  • コツズイシュ ゼンク サイボウ

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Abstract

Heterogenous biological character of myeloma cells was associated with different expression of adhesion molecules. Myeloma cells could be phenotypically divided into two subpopulations: CD38++/VLA5+/MPC-1+ (VLA-5+) cells and CD38++/VLA5-/MPC-1- (VLA-5-) cells. VLA-5- myeloma cells were morphologically immature and proliferated markedly with response to IL-6 in vitro, while VLA-5+ cells showed very low uptakes of 3H-TdR but secreted higher amounts of M-protein in vitro. These results suggest VLA-5- cells are proliferative precursor in myeloma. With respect to VLA-5 and MPC-1 expression, myeloma precursor cells (CD38++/VLA-5-/MPC-1-/CD10-/CD24-) showed similar phenotype to germinal center B cells (CD38+/VLA-5-/MPC-1-/CD10+/CD24-), rather than that of pre-B cells in the bone marrow (CD38+/VLA-5+/MPC-1-/CD10+/CD24+). Identification of precursor cells and characterization of their growth is important for the understanding of pathophysiology of myeloma and the therapeutic strategy.

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  • Rinsho Ketsueki

    Rinsho Ketsueki 34 (4), 433-438, 1993

    The Japanese Society of Hematology

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