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Myelodysplastic Syndrome Associated with Marked Eosinophilia and Basophilia
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- TANABE Juichi
- First Department of Internal Medicine, Yokohama City University
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- SASAKI Shin
- First Department of Internal Medicine, Yokohama City University
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- TAMURA Tomohiko
- First Department of Internal Medicine, Yokohama City University
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- OKAMOTO Rie
- First Department of Internal Medicine, Yokohama City University
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- SUGAMURA Rika
- First Department of Internal Medicine, Yokohama City University
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- FUJITA Hiroyuki
- First Department of Internal Medicine, Yokohama City University
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- FUKAWA Hitoshi
- First Department of Internal Medicine, Yokohama City University
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- KANAMORI Heiwa
- First Department of Internal Medicine, Yokohama City University
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- MATSUZAKI Michio
- First Department of Internal Medicine, Yokohama City University
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- MOHRI Hiroshi
- First Department of Internal Medicine, Yokohama City University
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- OKUBO Takao
- First Department of Internal Medicine, Yokohama City University
Bibliographic Information
- Other Title
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- 著明な好酸球・好塩基球増加を伴った骨髄異形成症候群の1例
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Description
Myelodysplastic syndrome (refractory anemia with excess of blasts; RAEB) with marked basophilia and eosinophilia is described. An 82-year-old male was admitted to our hospital because of severe normocytic normochromic anemia (Hb 5.6 g/dl). The white cell count was 9,200/μl with marked basophilia (34.5%) and eosinophilia (19.5%). The bone marrow aspiration also revealed both basophilia and eosinophilia, with blast contents of 9%. Diagnosis of RAEB was established. Although the treatment with red cell transfusion and ubenimex (Bastatin) was started, anemia was not improved. A karyotype of the bone marrow cells from this patient showed 47, XY, +8, i(17q), which has been observed as additional chromosomal abnormalities in blastic crisis of chronic myelogenous leukemia. The diagnosis of CML was not compatible with this case, because Ph1 chromosome and bcr gene rearrangement were negative. It is concluded that eosinophilia and basophilia might be derived from clonal abnormalities associated with MDS.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 33 (2), 189-193, 1992
The Japanese Society of Hematology
