表在リンパ節腫脹を認めず，巨大ひ腫を伴ったＣＤ５陰性Ｂ細胞性慢性リンパ性白血病

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タイトル別名
  • CD5-Negative B-Cell Chronic Lymphocytic Leukemia(B-CLL) Associated with Massive Splenomegaly and without Lymphadenopathy.
  • 表在リンパ節腫脹を認めず,巨大脾腫を伴ったCD5陰性B細胞性慢性リンパ性白血病
  • ヒョウザイ リンパセツ シュチョウ オ ミトメズ キョダイ ヒ シュ オ トモ

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A 39-year-old male was referred to our hospital in June, 1993, because of leukocytosis. Physical examinations showed massive splenomegaly without any lymphadenopathy. The white blood cell count was 13,800/μl with 87% morphologically mature lymphocytes. Bone marrow aspirate revealed hypercellularity with 67% lymphocytes morphologically similar to peripheral lymphocytes. The lymphocytes displayed monoclonal rearrangements of immunoglobulin genes and the phenotype of CD5-CD19+CD20+CD21+ and Smlg+. Splenectomy was effective against neutropenia and thrombocytopenia. The clinical and laboratory findings of this case were unusual compared to those of typical B-CLL in massive splenomegaly, no lymphadenopathy and CD5- phenotype, suggesting the heterogeneity of B-CLL.

収録刊行物

  • 臨床血液

    臨床血液 36 (10), 1230-1232, 1995

    一般社団法人 日本血液学会

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