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- AKIMOTO Yoshihisa
- Department of Hematology, Showa University School of Medicine
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- ISHIYAMA Taijiro
- Department of Hematology, Showa University School of Medicine
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- SANO Motoharu
- Department of Hematology, Showa University School of Medicine
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- UENO Hideyuki
- Department of Hematology, Showa University School of Medicine
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- NAKAMAKI Tsuyoshi
- Department of Hematology, Showa University School of Medicine
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- HINO Ken-ichiro
- Department of Hematology, Showa University School of Medicine
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- TOMOYASU Shigeru
- Department of Hematology, Showa University School of Medicine
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- TSURUOKA Nobuyoshi
- Department of Hematology, Showa University School of Medicine
Bibliographic Information
- Other Title
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- 本態性血小板血症の発症3年後に骨髄線維症に移行した1例
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Abstract
A 66-year-old man was presented with thrombocytosis in February, 1988. Laboratory examinations on admission revealed a white blood cell count of 17,700/μl and a platelet count of 274.4×104/μl. Bone marrow aspirates showed an increase of megakaryocytes (1,294/μl). There was no fibrosis or Ph1 chromosome. He was diagnosed as having essential thrombocythemia and was treated with thrombopheresis, carboquone and ranimustine (MCNU). Subsequently his platelet count was well controlled approximately for three years. He was readmitted because of pyrexia and left hypochondralgia in February 1991. Physical examination revealed hepatosplenomegaly. Peripheral blood revealed leukoerythroblastosis associated with the occurrence of tear drop cells. Bone marrow aspiration resulted in a dry tap and the biopsy specimen showed reticulin fibrosis. This is a fairly rare case of essential thrombocythemia that transformed to myelofibrosis.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 33 (4), 520-524, 1992
The Japanese Society of Hematology